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Jindrich Kopecek Selected Research

hydroxypropyl methacrylate

4/2010Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics.
11/2009Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
5/2009Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells.
1/2009Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.
9/2008Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting.
9/2008Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells.
5/2008Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates.
12/2007Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates.
2/2007Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
7/2006Water-soluble HPMA copolymer--prostaglandin E1 conjugates containing a cathepsin K sensitive spacer.
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Jindrich Kopecek Research Topics

Disease

11Neoplasms (Cancer)
02/2010 - 04/2002
10Carcinoma (Carcinomatosis)
11/2009 - 01/2002
3Osteoporosis
12/2007 - 07/2006
3Colonic Neoplasms (Colon Cancer)
02/2007 - 04/2002
3Ovarian Neoplasms (Ovarian Cancer)
05/2006 - 04/2002
2Prostatic Neoplasms (Prostate Cancer)
04/2010 - 05/2009
2Musculoskeletal Diseases (Musculoskeletal Disease)
02/2010 - 05/2005
2B-Cell Lymphoma (Lymphoma, B Cell)
11/2006 - 03/2006
1Pulmonary Edema
01/2011
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
01/2009
1Osteosarcoma (Osteogenic Sarcoma)
01/2009
1Neoplasm Metastasis (Metastasis)
01/2009
1Bone Resorption
09/2007
1Bone Diseases (Bone Disease)
07/2006
1Arthritis (Polyarthritis)
10/2004
1Rheumatoid Arthritis
07/2002
1Lymphoma (Lymphomas)
05/2002
1Breast Neoplasms (Breast Cancer)
04/2002

Drug/Important Bio-Agent (IBA)

18hydroxypropyl methacrylateIBA
04/2010 - 01/2002
11N-(2-hydroxypropyl)methacrylamideIBA
11/2009 - 04/2002
5PolymersIBA
01/2009 - 09/2002
5Pharmaceutical PreparationsIBA
09/2008 - 04/2002
4Doxorubicin (Adriamycin)FDA LinkGeneric
05/2006 - 04/2002
3Immunoglobulin Fab FragmentsIBA
09/2008 - 01/2002
2AntigensIBA
05/2009 - 09/2003
2AntibodiesIBA
05/2009 - 09/2008
2CaspasesIBA
05/2006 - 05/2004
2Peptides (Polypeptides)IBA
03/2006 - 05/2002
2Cell-Penetrating PeptidesIBA
08/2003 - 01/2003
19-aminocamptothecinIBA
11/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2009
1Angiogenesis InhibitorsIBA
01/2009
1meso-chlorin e(6) monoethylene diamineIBA
09/2008
1Biological ProductsIBA
09/2008
1ThiophenesIBA
09/2008
1DisulfidesIBA
05/2008
1Diphosphonates (Bisphosphonates)IBA
09/2007
1Alendronate (Alendronate Sodium)FDA LinkGeneric
09/2007
1ApatitesIBA
09/2007
1LigandsIBA
11/2006
1Tentagel resinIBA
11/2006
1Evans Blue (Blue, Evans)FDA Link
10/2004
1Serum AlbuminIBA
10/2004
1Fluorescent Dyes (Fluorescent Probes)IBA
05/2004
1FITC-annexin A5IBA
05/2004
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2004
1Caspase 3 (Caspase-3)IBA
05/2004
1Caspase 8 (Caspase-8)IBA
05/2004
1geldanamycinIBA
11/2003
117- (3- aminopropylamino)- 17- demethoxygeldanamycinIBA
11/2003
1Immunoglobulin FragmentsIBA
09/2003
1PolyethyleneimineIBA
09/2003
1poly(ethylene glycol)-co-poly(ethyleneimine)IBA
09/2003
1Surface Antigens (Surface Antigen)IBA
09/2003
1Catalytic RNA (Ribozymes)IBA
09/2002
1OligonucleotidesIBA
09/2002
1beta-galactosideIBA
08/2002
1LactoseFDA LinkGeneric
08/2002
1GlycosidesIBA
08/2002
1GlycoconjugatesIBA
08/2002
1Galactose (Galactopyranose)FDA LinkGeneric
08/2002
1GalactosamineIBA
08/2002
1LectinsIBA
08/2002
1Galectins (Galectin)IBA
08/2002
1SugarsIBA
08/2002
1Cathepsin KIBA
07/2002
1Proteins (Proteins, Gene)FDA Link
07/2002
1EnzymesIBA
07/2002
1Drug CarriersIBA
05/2002
1EpitopesIBA
05/2002
1OligopeptidesIBA
05/2002
1Hyaluronic Acid (Hyaluronan)IBA
04/2002

Therapy/Procedure

5Therapeutics
02/2010 - 09/2002
3Photochemotherapy (Photodynamic Therapy)
09/2008 - 01/2003
2Drug Therapy (Chemotherapy)
02/2005 - 01/2003
1Artificial Respiration (Mechanical Ventilation)
01/2011
1Critical Care (Surgical Intensive Care)
01/2011
1Combination Drug Therapy (Combination Chemotherapy)
09/2008